Omotola attended Chrisland School Opebi , Oxford Children School , and Command Secondary School, Kaduna and completed her studies at Yaba College of Technology, where she studied estate management.
Omotola was introduced to acting by accompanying a friend to an audition. Her first acting role was in the 1995 movie, Venom of Justice, directed by Reginald Ebere. She was given the lead role in the movie, which set the stage for a flourishing career in the Nollywood film industry. She got her first big role in the critically acclaimed film Mortal Inheritance (1995). In the movie, she played a sickle-cell patient who fights for her life despite the odds of survival. The film is regarded as one of Nigeria's best movies ever made. Since then, she has starred in several blockbuster movies, including Games Women Play, Blood Sisters, All My Life, Last Wedding, My Story, among others.
After a career defining role in Mortal Inheritance, her portrayal won her "Best Actress in an English Speaking Movie" and "Best Actress Overall" at the 1997 THEMA (The Movie Awards). She was the youngest actress in Nigeria at this time to achieve this feat.
Omotola has gone on to win over 40 domestic and international awards. She is considered Africa's biggest box office actress. In 2015, she celebrated her 20th anniversary in the entertainment industry. She has appeared in about 200 movies and is still rocking on. She is timeless, graceful and her aura is just sweet and infectious. I keep asking how one woman could possibly have all that "sexy" up her sleeves after kids. She seems to be drinking from the fountain of youth. lol